Details of the gameplay demo, taken from neogaf:
From the Impressions:
-Our main character, Sebastian, enters the asylum with two fellow detectives, a man named Joseph and a woman they simply call, 'The Kid',
-A lot of dead bodies are around the asylum, and on a video monitor Sebastian see's a hooded figure killing police, who then suddenly appears behind him and knocks him unconscious.
-Went out of their way to model human innards and gore to be detailed.
-Sebastian wakes up hanging upside down by a meta hook as a madman with a butcher knife and a blood-stained wife beater, comes in and cuts down a fellow person hanging alongside him, takes him to the table, and begins cutting him open.
-Based on if there's enemies around or not, the animations and potential speed of Sebastian changes.
-Sebastian alerts the butcher, who pulls out one of Mikami's infamous weapons, a chainsaw. Ensues a chase scene where our character is quite stumbly.
-When the chainsaw-wielding butcher does not sense Sebastian, he is erratic and swings around wildly. When spotted, he comes dashing after you. You can use things like empty bottles to throw to divert his attention.
-Escapes into an elevator, and then comes to a desperate run out of the hospital as it collapses in a very Jacob's Ladder-esque scene. Leaves out to see the Police Cars in a giant crater. Prologue ends there.
-Second part of the demo is later into the game, in a dark outside location heading to a small cottage. Inside are the 'garden-variety' zombie-esque enemies.
-The enemies have a theme of torment with them.
-While shooting out around the cottage for your life, a change happens in the environment as it sort of 'shifts' in the middle of combat and suddenly a scene out of the Shining happens with blood pouring and consuming Sebastian, and then he finds himself back in the asylum.
-Demo ends with a multi-legged wraith-type enemy bursting out of a pool of blood and rushing towards the player at break-neck speed.